Ryan Braun scored the winning run in the 11th inning off a wild pitch.
The Rockies won three of four games in the season-opening series.
Rockies won their second game against the Brewers 6-5
Eric Thames, Travis Shaw and Jonathan Villar each homered, Wily Peralta pitched five effective innings and the Milwaukee Brewers beat the Colorado Rockies 6-1 Wednesday night.
Guerra is out for a couple of games, but the Brewers have prepared for the circumstances.
Sloppy play and an injury to Guerra are too much for the Brewers to overcome.
Milwaukee Brewers have replaced every player on their roster, except Braun, since early 2015.
Milwaukee is set with fresh faces for opening day.
Relievers Tyler Cravy and Rob Scahill were told they would be reporting to Class AAA Colorado Springs, but they were not quiet about their disappointment.
Milwaukee replaced almost everyone on their roster, which opens doors for players who would not have made it out of the minor leagues in the past.